Goulon M, Gajdos P, Pilliot J
Nouv Presse Med. 1981 Feb 26;10(8):613-6.
Sixteen patients, 9 to 81 years old, with Gram-negative septicaemia have been treated with cefotaxime. In all cases, the patients were hospitalised in an intensive care unit for a severe infection distinct from septicaemia. Cefotaxime was given alone to 11 patients and was administered by infusion over 20 to 30 minutes, every 4 or 6 hours, in a daily dose of 67 to 94 mg/kg to patients with normal of subnormal renal function. Gram-negative pathogens were sensitive to cefotaxime (MIC less than 1 mcg/ml in most cases). A clinical cure was obtained in 14 patients. In all the cases, tolerance was good. The very low MIC's of cefotaxime and the results in severe Gram-negative septicaemia justify the use of cefotaxime in monotherapy, in patients with severe life-threatening infections, when blood cultures appear to be positive for Gram-negative pathogens, even without awaiting antibiograms.
16例年龄在9至81岁之间的革兰氏阴性菌败血症患者接受了头孢噻肟治疗。所有病例中，患者均因除败血症外的严重感染入住重症监护病房。11例患者单独使用头孢噻肟，对于肾功能正常或低下的患者，每4或6小时静脉输注20至30分钟，日剂量为67至94mg/kg。革兰氏阴性病原体对头孢噻肟敏感（大多数情况下MIC小于1mcg/ml）。14例患者获得临床治愈。所有病例中耐受性良好。头孢噻肟极低的MIC以及在严重革兰氏阴性菌败血症中的治疗结果证明，在严重危及生命的感染患者中，当血培养显示革兰氏阴性病原体呈阳性时，即使不等待药敏试验结果，也可使用头孢噻肟进行单药治疗。
