可降解淀粉微球诱导的短暂性肠缺血。猫实验。

Transient intestinal ischaemia induced by degradable starch microspheres. Experiments in the cat.

作者信息

Lote K, Følling M, Rosengren B, Svanes K, Lekven J

出版信息

Acta Radiol Oncol. 1980;19(5):343-51. doi: 10.3109/02841868009131318.

Abstract

Temporary ischaemia was induced in cat small intestine by degradable starch microspheres. Regional arterial and tissue blood flow immediately fell by 85 per cent with subsequent normalization within 26 min after microsphere injection. Degraded 99Tcm-labelled microspheres were exponentially removed from intestinal vessels and accumulated in the liver. Provided near-total arteriolar obstruction is induced, external isotope detection may permit assessment of the duration of the induced ischaemia, which implies a selection of the appropriate time for radiation therapy.

摘要

可降解淀粉微球诱导猫小肠出现暂时性缺血。微球注射后，局部动脉和组织血流立即下降85%，随后在26分钟内恢复正常。降解的99锝标记微球从肠道血管中呈指数级清除，并在肝脏中蓄积。如果诱导出现近乎完全的小动脉阻塞，外部同位素检测可能有助于评估诱导缺血的持续时间，这意味着可为放射治疗选择合适的时间。