醋酸环丙孕酮对性早熟儿童肾上腺皮质功能的影响。
Effect of cyproterone acetate on adrenocortical function in children with precocious puberty.
作者信息
Savage D C, Swift P G
出版信息
Arch Dis Child. 1981 Mar;56(3):218-22. doi: 10.1136/adc.56.3.218.
Abstract
Seven children with precocious puberty were treated with cyproterone acetate and their adrenal function studied. In each child the drug caused significant adrenal hypofunction which was secondary to adrenocorticotrophic hormone suppression. None of these children had clinical evidence of adrenal hypofunction and it is assumed that the drug has glucocorticoid-like properties. Children receiving cyproterone acetate should carry information to warn doctors of this effect since they may require steroid cover during illness.
摘要
对7名性早熟儿童使用醋酸环丙孕酮进行治疗，并对他们的肾上腺功能进行了研究。在每个儿童中，该药物均导致明显的肾上腺功能减退，这是促肾上腺皮质激素抑制的继发结果。这些儿童均无肾上腺功能减退的临床证据，推测该药物具有类糖皮质激素特性。接受醋酸环丙孕酮治疗的儿童应携带相关信息，以提醒医生注意这种效应，因为他们在患病期间可能需要使用类固醇进行掩护。
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