McMurphy D S, Ljung B
Acta Physiol Scand. 1978 Feb;102(2):218-23. doi: 10.1111/j.1748-1716.1978.tb06065.x.
Isolated portal veins from newborn and adult rats, rabbits, cats and guinea pigs were studied isometrically. Spontaneous activity and induced responses to transmural nerve stimulation (NS), noradrenaline, tyramine, acetylcholine and BaCl2 were quantitated. In agreement with our previous observations the portal veins of the newborn rat was found to lack spontaneous activity and responsiveness to applied stimuli whereas the newborn rabbit's portal vein showed inconsistent and weak responses. In the neonatal cat and guinea pig portal veins the pattern of the spontaneous activity and induced responses resembled those found in vessels from adult animals. It is concluded that the portal vein maturity at birth in several respects dramatic neuroeffector development of the portal vein during the postnatal period in the rat corresponds to prenatal events in cats and guinea pigs which are more highly developed at birth. Consequently, the lack of responsiveness of the portal vein during the first week of life does not seem to be secondary to the hormonal and hemodynamic adjustments during the neonatal period. Rather, the postnatal development of the rat portal vein occurs according to a genetically predetermined schedule, possible in parallel with the ontogenesis of vascular control in general.
对新生大鼠、成年大鼠、兔子、猫和豚鼠的离体门静脉进行了等长研究。对跨壁神经刺激（NS）、去甲肾上腺素、酪胺、乙酰胆碱和氯化钡的自发活动和诱发反应进行了定量分析。与我们之前的观察结果一致，发现新生大鼠的门静脉缺乏自发活动以及对施加刺激的反应能力，而新生兔子的门静脉反应不一致且较弱。在新生猫和豚鼠的门静脉中，自发活动和诱发反应的模式与成年动物血管中的模式相似。得出的结论是，在几个方面，出生时门静脉的成熟情况表明，大鼠出生后门静脉显著的神经效应器发育与猫和豚鼠出生时发育更完善的产前情况相对应。因此，出生后第一周门静脉缺乏反应能力似乎并非继发于新生儿期的激素和血液动力学调节。相反，大鼠门静脉的出生后发育是按照基因预先确定的时间表进行的，可能与一般血管控制的个体发生过程并行。
