Mautner R K, Katz G E, Iteld B J, Phillips J H
Chest. 1981 Apr;79(4):449-53. doi: 10.1378/chest.79.4.449.
A group of 14 patients with mitral valve prolapse syndrome was referred for coronary angiographic study. The group was selected on the basis that all members had recurrent chest pain as their chief complaint and all had interpreted their chest pain as serious enough to warrant at lest two previous emergency visits to medical facilities in the six months preceding the study. All were found to have normal left ventricular function, and only one had a significant fixed obstructive coronary lesion. Seven of 14 patients (50 percent) showed evidence of coronary artery spasm during the catheterization study, five of whom had histories highly suggestive of coronary vasospasm. During the catheterization, spasm occurred spontaneously in three patients, ws ergonovine-induced in two, and was catheter-tip-induced in two. Ergonovine was administered to nine of the 14 patients. The drug induced vasospasm in two patients but failed in seven (two of whom had previously demonstrated catheter tip spasm). Of those seven patients who showed evidence of spasm, four had typical chest pain in association with reversible ST segment elevation and manifested a variant anginal syndrome.
一组14例二尖瓣脱垂综合征患者被转诊进行冠状动脉造影研究。该组患者的入选标准是，所有成员均以反复胸痛为主要症状，且所有人都认为自己的胸痛严重到足以在研究前六个月内至少两次前往医疗机构进行急诊就诊。所有患者均被发现左心室功能正常，只有1例有明显的固定性阻塞性冠状动脉病变。14例患者中有7例（50%）在导管检查研究中显示有冠状动脉痉挛的证据，其中5例有高度提示冠状动脉痉挛的病史。在导管检查过程中，3例患者自发出现痉挛，2例由麦角新碱诱发，2例由导管尖端诱发。14例患者中有9例接受了麦角新碱治疗。该药物在2例患者中诱发了血管痉挛，但在7例患者中无效（其中2例先前已表现出导管尖端痉挛）。在这7例有痉挛证据的患者中，4例伴有典型胸痛并伴有可逆性ST段抬高，表现为变异型心绞痛综合征。
