戊巴比妥减缓了γ-氨基丁酸（GABA）从大鼠脑突触体结合位点的解离。

Pentobarbitone slows the dissociation of GABA from rat brain synaptosomal binding sites.

作者信息

Willow M, Johnston G A

出版信息

Neurosci Lett. 1981 Apr 9;23(1):71-4. doi: 10.1016/0304-3940(81)90189-0.

Abstract

The dissociation of GABA from rat brain synaptosomal binding sites is characterized by an initial rapid phase followed by a slower phase which may represent dissociation of GABA from high affinity binding sites. The dissociation rate constant (K-1) calculated from this secondary phase is significantly reduced by pentobarbitone (100 micrometers). This result supports the finding that barbiturates increase the affinity of GABA for a high affinity binding site.

摘要

γ-氨基丁酸（GABA）从大鼠脑突触体结合位点的解离具有两个阶段，先是一个快速的初始阶段，接着是一个较慢的阶段，后者可能代表GABA从高亲和力结合位点的解离。由该第二阶段计算得出的解离速率常数（K-1）被戊巴比妥（100微摩尔）显著降低。这一结果支持了巴比妥类药物会增加GABA对高亲和力结合位点的亲和力这一发现。