Boĭchenko M N, Zhilina I L, Elkina S I
Zh Mikrobiol Epidemiol Immunobiol. 1981 Jan(1):40-3.
The behavior of c-AMP-deficient S. typhimurium mutants in the culture of peritoneal macrophages of white mice and the antibacterial activity of immune macrophages obtained from mice previously immunized with c-AMP-deficient S. typhimurium mutants were studied; c-AMP-deficient mutants were shown to have a lesser cytotoxic effect on macrophages than the initial virulent strain, while retaining their capacity for intracellular proliferation. Immune macrophages acquired the ability to withstand the cytotoxic action of the virulent strain.
研究了c - AMP缺陷型鼠伤寒沙门氏菌突变体在小白鼠腹腔巨噬细胞培养中的行为，以及用c - AMP缺陷型鼠伤寒沙门氏菌突变体预先免疫的小鼠所获得的免疫巨噬细胞的抗菌活性；结果表明，c - AMP缺陷型突变体对巨噬细胞的细胞毒性作用比初始毒力菌株小，同时保留了其细胞内增殖能力。免疫巨噬细胞获得了抵抗毒力菌株细胞毒性作用的能力。
