格雷夫斯内分泌性眼病中致突眼性免疫球蛋白与促甲状腺免疫球蛋白的关系。

Relationship between exophthalmogenic and thyroid-stimulating immunoglobulins in Graves' endocrine ophthalmopathy.

作者信息

Leövey A, Kálmán K, Szabó T, Lente K, Sándor P, Balázs C

出版信息

Acta Med Acad Sci Hung. 1980;37(4):345-50.

Abstract

The effects of globulins from patients with Graves' infiltrative retrobulbar ophthalmopathy on the TSH binding inhibitory (TBIA) and stimulatory (TBSA) activities was examined utilising human thyroid Harderian gland (guinea-pig) plasma membranes in the TSh receptor assay. The changes of inhibitory and stimulatory activities of these globulins were observed following the preliminary incubation with human thyroid and Harderian gland plasma membranes. According to our data the TSh binding inhibitory activity of the globulins cases after saturating the samples with both thyroid and Harderian cell membranes. Whereas, their TSH-binding stimulatory activity ceases only after incubation with Harderian membrane. The TBSA of the samples after incubation with thyroid membrane increases significantly as compared to the values before incubation. We presume that the effects of the thyroid stimulating IgG (TSI) and the exophthalmogenic IgG (O-IgG) on the retrobulbar tissue are contradictory. It seems so the O-IgG is in some circumstances inhibited by TSI. Their TSH-binding inhibitory and stimulatory activities may depend on their quantitative ratio.

摘要

利用人甲状腺哈氏腺（豚鼠）质膜进行促甲状腺激素（TSH）受体测定，研究了格雷夫斯浸润性眼球后眼病患者球蛋白对TSH结合抑制（TBIA）和刺激（TBSA）活性的影响。在将这些球蛋白与人甲状腺和哈氏腺质膜进行预孵育后，观察了它们抑制和刺激活性的变化。根据我们的数据，在用甲状腺和哈氏腺细胞膜使样品饱和后，球蛋白的TSH结合抑制活性出现。然而，它们的TSH结合刺激活性仅在与哈氏腺膜孵育后才停止。与孵育前的值相比，样品与甲状腺膜孵育后的TBSA显著增加。我们推测甲状腺刺激IgG（TSI）和致突眼IgG（O-IgG）对眼球后组织的作用是相互矛盾的。在某些情况下，O-IgG似乎受到TSI的抑制。它们的TSH结合抑制和刺激活性可能取决于它们的定量比例。