Urinary excretion of cyclic-AMP and cyclic-GMP in allergic children throughout seven months of hyposensitization treatment.

The authors studied urine excretion of cyclic-AMP and cyclic-GMP in normal and allergic children before and after hyposensitization to house dust. The cyclic-AMP excretion was found to b diminished in the asthmatic group before the treatment. The hyposensitization did not modify these low levels. No significant variation of cyclic-GMP excretion was found among the normal, ante or post-hyposensitization asthmatic groups.