Zweifler A J, Julius S, Nicholls M G
Arch Intern Med. 1981 Jun;141(7):907-10.
The antihypertensive effect of captopril was assessed during short- and long-term periods in ten patients with elevated blood pressure readings that were uncontrollable by standard therapy (supine diastolic blood pressure of greater than 100 mm Hg with a regimen of propranolol hydrochloride, hydralazine hydrochloride, and hydrochlorothiazide). When given alone, captopril therapy was unable to normalize the blood pressure in any patient. The addition of hydrochlorothiazide to the captopril therapy normalized the blood pressure in one patient and sharply improved the blood pressure in four others. The blood pressure in the remaining patients responded inadequately to this combination. The addition of propranolol to captopril and hydrochlorothiazide reduced the blood pressure further in most cases (seven on the ten patients had normal blood pressure readings while they received these three drugs). In four patients, the blood pressure response to the added propranolol was unrelated to changes in plasma angiotensin II concentration. Captopril was helpful in the management of refractory hypertension in most cases.
在短期和长期内，对10例血压升高且标准治疗（使用盐酸普萘洛尔、盐酸肼屈嗪和氢氯噻嗪方案时仰卧位舒张压大于100 mmHg）无法控制的患者评估了卡托普利的降压效果。单独使用卡托普利治疗时，没有任何患者的血压能够恢复正常。在卡托普利治疗中加用氢氯噻嗪后，1例患者血压恢复正常，另外4例患者血压明显改善。其余患者对这种联合用药反应欠佳。在卡托普利和氢氯噻嗪基础上加用普萘洛尔，多数情况下血压进一步降低（10例患者中有7例在接受这三种药物治疗时血压读数正常）。在4例患者中，加用普萘洛尔后的血压反应与血浆血管紧张素II浓度变化无关。多数情况下，卡托普利有助于难治性高血压的治疗。
