Le Quesne L P
Am J Surg. 1978 Mar;135(3):421-5. doi: 10.1016/0002-9610(78)90078-8.
The development of the 125I-fibrinogen technic in the diagnosis of postoperative deep vein thrombosis provides a valuable tool for the study of the condition itself and of the efficacy of prophylactic measures. These measures may be divided into two groups: the antistasis regimes and the antithrombotic regimes. Published reports based on the 125I-fibrinogen technic are critically reviewed. Although many regimes cause a significant diminution in the incidence of isotopically detected deep vein thrombosis, 90 per cent of which are confined to the calf, this does not necessarily imply a similar diminution in the incidence of major pulmonary emboli, most of which arise from thrombi in the proximal segment of the lower limb veins. The origin of these proximal thrombi, with particular reference to their relationship to calf thrombi, is discussed. The reported studies of the influence of antithrombotic regimes on the incidence of pulmonary embolism are reviewed. It is concluded that a reduction in the incidence of isotopically detected deep vein thrombosis is probably accompanied by a significant reduction in the incidence of major pulmonary embolism, but further studies are required.
125I-纤维蛋白原技术在术后深静脉血栓形成诊断中的发展为研究该病症本身及预防措施的疗效提供了一种有价值的工具。这些措施可分为两组：抗淤滞方案和抗血栓形成方案。对基于125I-纤维蛋白原技术发表的报告进行了批判性综述。尽管许多方案使同位素检测到的深静脉血栓形成发生率显著降低，其中90%局限于小腿，但这不一定意味着主要肺栓塞的发生率有类似降低，大多数主要肺栓塞源于下肢静脉近端段的血栓。讨论了这些近端血栓的起源，特别是它们与小腿血栓的关系。综述了关于抗血栓形成方案对肺栓塞发生率影响的报告研究。得出的结论是，同位素检测到的深静脉血栓形成发生率降低可能伴随着主要肺栓塞发生率的显著降低，但还需要进一步研究。
