应激和促肾上腺皮质激素对伏隔核和前额叶皮质中多巴胺代谢的影响。
Effect of stress and ACTH on dopamine metabolism in the nucleus accumbens and frontal cortex.
作者信息
Fadda F, Liguori G
出版信息
Boll Soc Ital Biol Sper. 1981 Feb 28;57(4):454-8.
PMID:6263300
Abstract
The effect of ACTH and electric foot shock stress on DOPAC content were determined in the frontal cortex and nucleus accumbens. Twenty min of stress enhanced DOPAC levels in the frontal cortex and in the nucleus accumbens by about 80% and 35%, respectively. On the other hand, a single dose of ACTH failed to change DOPAC concentration in the above brain areas. The present results show that the activation of mesolimbic and mesocortical dopaminergic systems is not mediated by ACTH secretion.
摘要
促肾上腺皮质激素（ACTH）和足部电击应激对额叶皮质和伏隔核中3,4-二羟基苯乙酸（DOPAC）含量的影响已被测定。20分钟的应激分别使额叶皮质和伏隔核中的DOPAC水平提高了约80%和35%。另一方面，单剂量的ACTH未能改变上述脑区中DOPAC的浓度。目前的结果表明，中脑边缘和中脑皮质多巴胺能系统的激活不是由ACTH分泌介导的。
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