Belluzzi O, Perri V
Boll Soc Ital Biol Sper. 1981 Feb 28;57(4):459-63.
PGE1 10(-7) M reversibly inhibits impulse transmission at the synapses of the guinea-pig isolated superior cervical ganglion. Neither resting potential nor membrane resistance of the sympathetic neurons were affected by PGE treatment. Quantal analysis of transmitter release shows that in the presence of PGs the quantum size is not significantly changed while the quantum content appears to be consistently reduced. It is suggested that PGE modulates synaptic transmission in the guinea-pig superior cervical ganglion by inhibiting acetylcholine release from presynaptic terminals.
前列腺素E1（PGE1）10⁻⁷ M可可逆性抑制豚鼠离体颈上神经节突触处的冲动传递。前列腺素E（PGE）处理对交感神经元的静息电位和膜电阻均无影响。对递质释放的量子分析表明，在存在前列腺素的情况下，量子大小无明显变化，而量子含量似乎持续减少。提示PGE通过抑制突触前终末乙酰胆碱的释放来调节豚鼠颈上神经节的突触传递。
