Hertz L, Richardson J S, Mukerji S
Can J Physiol Pharmacol. 1980 Dec;58(12):1515-9. doi: 10.1139/y80-230.
Doxepin binds to intact astrocytes in primary cultures. The binding is competitively displaceable by excess cold doxepin and it is pronounced (Bmax = 27 nmol/mg protein) but the affinity is rather low (KD = 30 microM). The binding is inhibited by other antidepressants (amitriptyline, desipramine, tranylcypromine, iprindole) and propranolol but not by isoproterenol. Nevertheless, doxepin counteracts effectively the increase in the production of cyclic AMP evoked by isoproterenol.
多塞平与原代培养中的完整星形胶质细胞结合。这种结合可被过量的冷多塞平竞争性取代，且结合明显（Bmax = 27 nmol/mg蛋白质），但亲和力相当低（KD = 30 μM）。其他抗抑郁药（阿米替林、地昔帕明、反苯环丙胺、茚满二氮卓）和普萘洛尔可抑制这种结合，但异丙肾上腺素无此作用。然而，多塞平可有效对抗异丙肾上腺素引起的环磷酸腺苷生成增加。
