Lefall L D
Cancer. 1981 Mar 1;47(5 Suppl):1170-2. doi: 10.1002/1097-0142(19810301)47:5+<1170::aid-cncr2820471319>3.0.co;2-s.
The American Cancer Society estimates that during 1980, there will be approximately 114,000 new cases of colorectal cancer in the United States--second only to lung cancer (an expected 117,000 cases) in incidence for internal malignant neoplasms. There will be 53,000 deaths this year from colorectal cancer. The low five-year survival rate of 42% in related primarily to late diagnosis. Therefore effective methods of making an earlier diagnosis are important. The use of fecal occult blood testing and sigmoidoscopic examination (rigid or flexible) appear to be tools that will make earlier diagnoses of colorectal cancer. Colonoscopy and barium enema are indicated if symptoms of colorectal cancer are present or if indicated from findings noted on fecal occult blood testing or sigmoidscopy. Determinations of carcinoembryonic antigen levels are of no practical value in colorectal cancer screening. In asymptomatic patients, fecal occult blood testing is recommended annually beginning at age 50, while sigmoidoscopy should be performed at age 50, repeat in one year, then performed every three years. The two chief areas of interest in colorectal cancer prevention are the removal of neoplastic polyps at the time of endoscopy, and the role of nutrition to decrease fat and increase fiber in the diet.
美国癌症协会估计,1980年美国将有大约11.4万例新的结肠直肠癌病例——在国内恶性肿瘤发病率中仅次于肺癌(预计11.7万例)。今年将有5.3万人死于结肠直肠癌。相关的五年生存率低至42%,主要与诊断延迟有关。因此,有效的早期诊断方法很重要。粪便潜血检测和乙状结肠镜检查(硬性或软性)似乎是能够实现结肠直肠癌早期诊断的工具。如果出现结肠直肠癌症状,或者根据粪便潜血检测或乙状结肠镜检查的结果有指征时,则需进行结肠镜检查和钡灌肠检查。癌胚抗原水平的测定在结肠直肠癌筛查中没有实际价值。对于无症状患者,建议从50岁开始每年进行粪便潜血检测,50岁时进行乙状结肠镜检查,一年后复查,然后每三年进行一次。结肠直肠癌预防的两个主要关注领域是在内镜检查时切除肿瘤性息肉,以及营养在减少饮食中的脂肪和增加纤维方面的作用。