Lapin I P
Epilepsia. 1981 Jun;22(3):257-65. doi: 10.1111/j.1528-1157.1981.tb04108.x.
Recent data and concepts concerning the convulsant effects of kynurenines, neuroactive metabolites of tryptophan, in mice, rats, and frogs are reviewed. Myoclonic seizures of the hindlegs are induced in mice by l- and d,l-kynurenine. Both l- and d,l-kynurenine exhibit a selective synergism with strychnine. The convulsant effect of l-kynurenine is selectively antagonized by taurine, less selectively by l-glycine, and not at all by gamma-aminobutyric acid (GABA) or the GABA agonist muscimol. Derivatives of GABA and some standard anticonvulsant drugs alter seizures induced by l-kynurenine and quinolinic acid in different ways. The involvement of brian kynurenines in the genesis of epileptic seizures is suggested.
本文综述了近期关于色氨酸的神经活性代谢产物犬尿氨酸对小鼠、大鼠和青蛙惊厥作用的数据和概念。L-犬尿氨酸和DL-犬尿氨酸可诱发小鼠后肢肌阵挛性惊厥。L-犬尿氨酸和DL-犬尿氨酸均与士的宁表现出选择性协同作用。L-犬尿氨酸的惊厥作用可被牛磺酸选择性拮抗，被L-甘氨酸的拮抗作用稍弱，而不被γ-氨基丁酸（GABA）或GABA激动剂蝇蕈醇拮抗。GABA衍生物和一些标准抗惊厥药物以不同方式改变由L-犬尿氨酸和喹啉酸诱发的惊厥。提示脑内犬尿氨酸参与癫痫发作的发生。
