Rassweiler J, Kauffmann G W, Rohrbach R, Richter G
Rofo. 1980 Dec;133(6):644-53. doi: 10.1055/s-2008-1056808.
Effect of tumor embolization is limited by parasitary blood supply. The influence of those collaterals should be decreased by transporting the embolization medium into the capillaries and tumor sinusoids. Controlled and safe capillary embolization is developed from studies of obtainable radiodensity, viscosity, and occlusion mechanism of Gelfoam-powder, IBC, and Ethibloc. The efficiency of these substances is compared to simple arterial ligation in experimental series with 400 Wistar rats. It is shown that ligation is comparable to insufficient capillary transport of the medium leaving islands of microscopically intact parenchyma. Easy application and total necrosis is guaranteed only by Ethibloc. Success of embolization is strictly volume dependent. Preinjected glucose is mandatory for homogenous distribution and peripheral transport.
肿瘤栓塞的效果受到寄生性血供的限制。通过将栓塞介质输送到毛细血管和肿瘤血窦中,应降低这些侧支循环的影响。基于对明胶海绵粉、碘油和乙基纤维素的可获得的放射密度、粘度和闭塞机制的研究,开发出了可控且安全的毛细血管栓塞。在对400只Wistar大鼠进行的实验系列中,将这些物质的效果与单纯动脉结扎进行了比较。结果表明,结扎相当于介质的毛细血管输送不足,留下了显微镜下完整的实质岛。只有乙基纤维素能保证易于应用和完全坏死。栓塞的成功严格依赖于体积。预先注射葡萄糖对于均匀分布和外周输送是必不可少的。