Fulton D S, Levin V A, Wara W M, Edwards M S, Wilson C B
J Neurosurg. 1981 Jun;54(6):721-5. doi: 10.3171/jns.1981.54.6.0721.
Forty-five children harboring brain-stem tumors were treated at the University of California, San Francisco, between 1969 and 1979. Pathological diagnoses were made in 19 patients. All patients received radiation therapy (RT). Thirteen patients received chemotherapy before, during, or immediately after RT. Twenty-four patients were treated with chemotherapy at the time of tumor progression, after initial treatment with RT alone. No statistically significant difference in time to tumor progression or survival was found for treatment with chemotherapy as an adjuvant to RT compared to treatment with RT alone followed by chemotherapy administered at the time of tumor progression. There were, however, more long-term survivors in the group that was first treated with chemotherapy at the time of tumor progression. There was no statistically significant correlation between survival and tumor pathology or location, although there were more long-term survivors among patients harboring low-grade gliomas and among patients with tumors confined to the midbrain. The authors documented the response of some brain-stem tumors to chemotherapy; however, cooperative controlled studies will be required to determine the optimum treatment for this disease.
1969年至1979年间，45名患有脑干肿瘤的儿童在加利福尼亚大学旧金山分校接受了治疗。19名患者进行了病理诊断。所有患者均接受了放射治疗（RT）。13名患者在RT之前、期间或之后立即接受了化疗。24名患者在仅接受RT初始治疗后肿瘤进展时接受了化疗。与仅接受RT然后在肿瘤进展时给予化疗相比，RT辅助化疗在肿瘤进展时间或生存率方面未发现统计学上的显著差异。然而，在肿瘤进展时首先接受化疗的组中有更多的长期存活者。生存与肿瘤病理或位置之间没有统计学上的显著相关性，尽管在患有低级别胶质瘤的患者和肿瘤局限于中脑的患者中有更多的长期存活者。作者记录了一些脑干肿瘤对化疗的反应；然而，需要进行合作对照研究来确定这种疾病的最佳治疗方法。
