一种神经七肽对老年人认知功能的影响。

A neuroheptapeptide influence on cognitive functioning in the elderly.

作者信息

Miller L H, Groves G A, Bopp M J, Kastin A J

出版信息

Peptides. 1980 Spring;1(1):55-7. doi: 10.1016/0196-9781(80)90036-4.

Abstract

The heptapeptide core common to melanocyte-stimulating hormone (MSH) and adrenocorticotropin (ACTH) was administered as a single subcutaneous dose of 30 mg to 13 elderly human subjects (9 men, 4 women) in a double-blind, cross-over design. Significant improvement was found in the Benton Visual Retention Test after MSH/ACTH 4--10 as compared with administration of saline. This appeared to be greater in men than women. No side effects or laboratory abnormalities were observed. The behavioral results are consistent with our earlier findings in men and rats of improved visual attention after administration of MSH and extend them to the elderly population.

摘要

将促黑素细胞激素（MSH）和促肾上腺皮质激素（ACTH）共有的七肽核心以30毫克的单次皮下剂量给予13名老年受试者（9名男性，4名女性），采用双盲交叉设计。与给予生理盐水相比，在给予MSH/ACTH 4-10后，本顿视觉保持测验有显著改善。这在男性中似乎比女性更明显。未观察到副作用或实验室异常。行为学结果与我们早期在男性和大鼠中给予MSH后视觉注意力改善的发现一致，并将这些发现扩展到了老年人群体。