一种生物振荡模型。
A model for biological oscillations.
作者信息
Chay T R
出版信息
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2204-7. doi: 10.1073/pnas.78.4.2204.
Abstract
A model and computation for oscillatory phenomena observed in some biological processes that utilize ion gradients across a membrane is presented. The model contains two main features: (i) active H+ transport pathways in the membrane and (ii) key enzymes having a pH-dependent activity profile and either translocating H+ from outside or producing H+ as a product. With this model a very long period of oscillations, as observed in mitochondrial and circadian rhythms, could be quantitatively demonstrated.
摘要
本文提出了一个模型及计算方法，用于描述在一些利用跨膜离子梯度的生物过程中观察到的振荡现象。该模型包含两个主要特征：（i）膜中的主动H⁺转运途径；（ii）具有pH依赖性活性曲线且能将H⁺从外部转运或产生H⁺作为产物的关键酶。利用这个模型，可以定量地证明线粒体和昼夜节律中观察到的非常长周期的振荡。
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本文引用的文献
1
Daily Rhythm of Luciferin Activity in Gonyaulax polyedra.多甲藻的荧光素活性的日周期。
Science. 1963 Sep 6;141(3584):913-5. doi: 10.1126/science.141.3584.913.
2
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism.通过化学渗透机制将磷酸化与电子及氢转移相偶联。
Nature. 1961 Jul 8;191:144-8. doi: 10.1038/191144a0.
3
Proton transport across charged membrane and pH oscillations.质子跨带电膜的运输与pH振荡。
Biophys J. 1980 Apr;30(1):99-118. doi: 10.1016/S0006-3495(80)85079-X.
4
Cell aggregation and differentiation in Dictyostelium.盘基网柄菌中的细胞聚集与分化。
Curr Top Dev Biol. 1968;3:157-97. doi: 10.1016/s0070-2153(08)60354-3.
5
A physiological model for circadian rhythms derived from the acetabularia rhythm paradoxes.源自伞藻节律悖论的昼夜节律生理模型。
Int J Chronobiol. 1974;2(1):25-33.
6
Membrane model for the circadian clock.生物钟的膜模型。
Nature. 1974 Mar 8;248(5444):116-20. doi: 10.1038/248116a0.
7
A timekeeping enzyme in the pineal gland.
Sci Am. 1979 Apr;240(4):66-71. doi: 10.1038/scientificamerican0479-66.
8
Electron transfer: pathways, mechanisms, and controls.
Annu Rev Biochem. 1977;46:967-80. doi: 10.1146/annurev.bi.46.070177.004535.
9
Proton translocation reactions in the respiratory chains.呼吸链中的质子转运反应。
Biochim Biophys Acta. 1976 Apr 30;456(1):39-84. doi: 10.1016/0304-4173(76)90008-2.
10
A biochemical model of the circadian clock.
J Theor Biol. 1975 Dec;55(2):455-70. doi: 10.1016/s0022-5193(75)80093-2.
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