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Epidermal growth factors enhances viral transformation of granulosa cells.

作者信息

Harrison J, Auersperg N

出版信息

Science. 1981 Jul 10;213(4504):218-9. doi: 10.1126/science.6264597.

DOI:10.1126/science.6264597
PMID:6264597
Abstract

Kirsten sarcoma virus produced a low incidence of transient morphological transformation in primary cultures of rat ovarian granulosa cells. In the presence of epidermal growth factor, the incidence of transient transformation increased severalfold and two continuous cell lines were established. Epidermal growth factor, a naturally occurring polypeptide hormone, appears to act here as a tumor promoter in the retrovirus-induced transformation of a mesodermally derived epithelium.

摘要

相似文献

1
Epidermal growth factors enhances viral transformation of granulosa cells.
Science. 1981 Jul 10;213(4504):218-9. doi: 10.1126/science.6264597.
2
Morphological transformation of cells induced by Kirsten sarcoma virus transforming factor is independent of serine proteases.
J Cell Physiol. 1982 Jan;110(1):81-3. doi: 10.1002/jcp.1041100113.
3
Cell-mediated co-action of transforming growth factors: incubation of type beta with normal rat kidney cells produces a soluble activity that prolongs the ruffling response to type alpha.转化生长因子的细胞介导协同作用：β型转化生长因子与正常大鼠肾细胞孵育产生一种可溶性活性物质，可延长对α型转化生长因子的皱襞反应。
J Cell Biol. 1986 Apr;102(4):1230-4. doi: 10.1083/jcb.102.4.1230.
4
A candidate rat-specific gene product of the Kirsten murine sarcoma virus.一种克尔斯滕鼠肉瘤病毒的候选大鼠特异性基因产物。
Virology. 1979 Nov;99(1):31-48. doi: 10.1016/0042-6822(79)90034-5.
5
Interferon inhibits transformation by murine sarcoma viruses before integration of provirus.在原病毒整合之前，干扰素可抑制鼠肉瘤病毒的转化作用。
Nature. 1980 Nov 6;288(5786):93-5. doi: 10.1038/288093a0.
6
Latent beta-transforming growth factor in nontransformed and Kirsten sarcoma virus-transformed normal rat kidney cells, clone 49F.未转化及经 Kirsten 肉瘤病毒转化的正常大鼠肾细胞克隆 49F 中的潜伏性β-转化生长因子
Cancer Res. 1984 Dec;44(12 Pt 1):5538-43.
7
ASP56/LDHk, the Kirsten sarcoma virus, and human cancer.ASP56/LDHk、柯斯顿肉瘤病毒与人类癌症。
Prog Clin Biol Res. 1983;119:185-98.
8
Dibutyryl cAMP inhibits expression of transformation-related properties in Kirsten murine sarcoma virus transformed Balb/c-3T3 cells despite continued presence of p21v-Ki-ras.二丁酰环磷腺苷抑制 Kirsten 小鼠肉瘤病毒转化的 Balb/c-3T3 细胞中与转化相关特性的表达，尽管 p21v-Ki-ras 持续存在。
Biochem Cell Biol. 1988 Jan;66(1):54-65. doi: 10.1139/o88-007.
9
Mutants of nonproducer cell lines transformed by murine sarcoma virus. IV. Multiplicity of proviral sequences and persistent viral production.
Intervirology. 1983;19(3):149-54. doi: 10.1159/000149350.
10
An agent or agents produced by virus-transformed cells cause unregulated ruffling in untransformed cells.病毒转化细胞产生的一种或多种因子会导致未转化细胞出现不受调控的边缘波动。
J Cell Biol. 1986 Apr;102(4):1224-9. doi: 10.1083/jcb.102.4.1224.

引用本文的文献

1
Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes.促有丝分裂激素和肿瘤启动子大大增加了携带扩增二氢叶酸还原酶基因的集落形成细胞的发生率。
Proc Natl Acad Sci U S A. 1983 Sep;80(17):5330-4. doi: 10.1073/pnas.80.17.5330.
2
Genome structure of mink cell focus-forming murine leukemia virus in epithelial mink lung cells transformed vitro by iododeoxyuridine-induced C3H/MuLV cells.在碘脱氧尿苷诱导的C3H/MuLV细胞体外转化的上皮性水貂肺细胞中，水貂细胞灶形成型鼠白血病病毒的基因组结构
J Virol. 1983 Feb;45(2):740-54. doi: 10.1128/JVI.45.2.740-754.1983.
3
Evidence for the involvement of the submandibular gland epidermal growth factor in mouse mammary tumorigenesis.
下颌下腺表皮生长因子参与小鼠乳腺肿瘤发生的证据。
Proc Natl Acad Sci U S A. 1985 Sep;82(17):5940-3. doi: 10.1073/pnas.82.17.5940.
4
Growth stimulation and apoptosis induced in cultures of neonatal rat liver cells by repeated exposures to epidermal growth factor/urogastrone with or without associated pancreatic hormones.通过反复暴露于表皮生长因子/尿抑胃素（无论是否伴有胰腺激素）在新生大鼠肝细胞培养物中诱导的生长刺激和细胞凋亡。
Cell Tissue Res. 1986;245(3):471-80. doi: 10.1007/BF00218546.
5
Detection of an intracellular transforming protein (v-Ki-ras p21) using the flow activated cell sorter (FACS).使用流式细胞分选仪（FACS）检测细胞内转化蛋白（v-Ki-ras p21）。
In Vitro Cell Dev Biol. 1986 Oct;22(10):621-4. doi: 10.1007/BF02623522.
6
Expression of viral p21ras during acquisition of a transformed phenotype by rat adrenal cortex cells infected with Kirsten murine sarcoma virus.在感染了 Kirsten 小鼠肉瘤病毒的大鼠肾上腺皮质细胞获得转化表型过程中病毒 p21ras 的表达
Mol Cell Biol. 1986 Jan;6(1):342-6. doi: 10.1128/mcb.6.1.342-346.1986.