围产期暴露于大麻二酚和Δ9-四氢大麻酚：对幼崽活力及成年雄性生殖系统的单独和联合影响。

Perinatal exposure to cannabichromene and delta 9-tetrahydrocannabinol: separate and combined effects on viability of pups and on male reproductive system at maturity.

作者信息

Hatoum N S, Davis W M, Elsohly M A, Turner C E

出版信息

Toxicol Lett. 1981 May;8(3):141-6. doi: 10.1016/0378-4274(81)90042-4.

Abstract

The effects of cannabichromene (CBC), delta 9-tetrahydrocannabinol (delta 9-THC) and their combination (all doses 50 mg/kg orally) were determined after being administered to female mice for 7 days beginning on the 20th day of gestation. The THC treatment reduced postnatal viability, impaired male reproductive behavior at maturity and significantly reduced seminal vesicle weights. No changes from control values occurred after CBC or CBC + THC. Thus, CBC alone at this dosage did not act like THC; moreover, it antagonized the effects of THC when the two were given in combination.

摘要

从妊娠第20天开始，对雌性小鼠连续7天口服给予大麻二酚（CBC）、Δ9-四氢大麻酚（Δ9-THC）及其组合（所有剂量均为50 mg/kg），然后测定其效果。THC处理降低了产后存活率，损害了雄性小鼠成年后的生殖行为，并显著降低了精囊重量。CBC或CBC + THC处理后，各项指标与对照组相比均无变化。因此，该剂量的单独CBC不像THC那样起作用；此外，当两者联合使用时，CBC可拮抗THC的作用。