Rose J C, Morris M, Meis P J
Am J Physiol. 1981 Jun;240(6):E585-90. doi: 10.1152/ajpendo.1981.240.6.E585.
Arterial blood pressure, central venous pressure, and plasma concentrations of ACTH, cortisol, and vasopressin (AVP) were monitored in chronically prepared, unanesthetized newborn and weanling lambs at rest and during and after hemorrhage of 15% of estimated blood volume at 1.5%/min. Differences in the endocrine and blood pressure responses to hypovolemia were noted in the two groups of animals. Hemorrhage did not change arterial mean pressure, reduced central venous pressure, and caused a delayed increase in the plasma concentrations of ACTH, cortisol, and AVP in the newborn lambs. In weanling lambs, hemorrhage reduced arterial mean pressure and central venous pressure and promptly increased plasma ACTH and cortisol levels while plasma AVP concentrations again showed a delayed increase. The data indicate that certain hormonal mechanisms for the defense of blood volume are present and operational within 3 days of birth and that age-related differences in the responses to hemorrhage exist in the lamb.
在长期准备、未麻醉的新生和断奶羔羊休息时，以及以1.5%/分钟的速度出血估计血容量的15%期间和之后，监测动脉血压、中心静脉压以及促肾上腺皮质激素（ACTH）、皮质醇和血管加压素（AVP）的血浆浓度。注意到两组动物对低血容量的内分泌和血压反应存在差异。出血未改变新生羔羊的动脉平均压，降低了中心静脉压，并导致ACTH、皮质醇和AVP的血浆浓度延迟升高。在断奶羔羊中，出血降低了动脉平均压和中心静脉压，并迅速提高了血浆ACTH和皮质醇水平，而血浆AVP浓度再次出现延迟升高。数据表明，出生后3天内存在并运行某些用于维持血容量的激素机制，并且羔羊对出血的反应存在与年龄相关的差异。
