Turpin J C, Hauw J J, Pollet S, Le Saux F, Escourolle R, Baumann N
Arch Neurol. 1981 Jul;38(7):436-8. doi: 10.1001/archneur.1981.00510070070012.
We performed a lipid analysis on nerve biopsy specimens in two cases of degenerative hypertrophic neuropathy. Quantitative analysis of the major lipid classes, ie, cholesterol, cerebrosides, sulfatides, ethanolamine phospholipids, phosphatidyl-choline, phosphatidyl-serine, phosphatidyl-inositol, sphingomyelin, and gangliosides, were performed. The two cases exhibited extreme decreases in levels of lipids that could be related to the very low myelin content of these nerves. Cholesterol and phospholipid levels were especially reduced. Cerebrosides and sulfatides were not modified in the same proportion, as could have been predicted from the degree of demyelination. This relative glycolipid increase could be due to the very high Schwann cell proliferation.
我们对两例退行性肥厚性神经病变患者的神经活检标本进行了脂质分析。对主要脂质类别，即胆固醇、脑苷脂、硫脂、乙醇胺磷脂、磷脂酰胆碱、磷脂酰丝氨酸、磷脂酰肌醇、鞘磷脂和神经节苷脂进行了定量分析。这两例患者的脂质水平极度降低，这可能与这些神经的髓鞘含量极低有关。胆固醇和磷脂水平尤其降低。脑苷脂和硫脂的变化比例与脱髓鞘程度的预期不同。这种相对糖脂增加可能是由于施万细胞的高度增殖。
