Bloch V, Laroche S
Behav Brain Res. 1981 Jul;3(1):23-42. doi: 10.1016/0166-4328(81)90026-7.
Neuronal activity, recorded in the dorsal hippocampus (CA3) during classical conditioning, was studied in rats receiving mild post-trial stimulation of the mesencephalic reticular formation. Hippocampal multi-unit activity increased in response to an auditory signal (conditioned stimulus) after pairing of the signal with a footshock (unconditioned stimulus), while the auditory signal alone, presented before conditioning, did not change the rate of hippocampal cell discharges. Trial-by-trial analysis of hippocampal multi-unit responses to the conditioned stimulus, both during acquisition and during a test of long-term retention, indicated that post-trial mesencephalic reticular stimulation hastened the onset of cellular conditioning and facilitated conversion to long-term storage. A study of evoked potentials recorded in the hippocampal formation to stimulation of the perforant path in awake rats, suggested that these effects could be mediated through a modulation of synaptic efficiency within hippocampal neuronal networks. These data are discussed in relation to the concept of neural perseveration in memory consolidation.
在经典条件反射过程中，对接受中脑网状结构轻度试验后刺激的大鼠，研究其背侧海马体（CA3）记录的神经元活动。在将听觉信号（条件刺激）与足部电击（非条件刺激）配对后，海马体多单位活动对听觉信号产生反应而增加，而在条件反射之前单独呈现的听觉信号并未改变海马体细胞放电率。对获取过程中和长期记忆测试期间海马体多单位对条件刺激的反应进行逐次试验分析表明，试验后中脑网状刺激加速了细胞条件反射的开始，并促进了向长期存储的转化。对清醒大鼠海马结构中刺激穿通路径所记录的诱发电位的研究表明，这些效应可能是通过调节海马神经元网络内的突触效率来介导的。结合记忆巩固中的神经持续概念对这些数据进行了讨论。
