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1
alpha 1-adrenoceptors can mediate chronotropic responses in the rat heart.α1肾上腺素能受体可介导大鼠心脏的变时反应。
Br J Pharmacol. 1981 Jul;73(3):586-8. doi: 10.1111/j.1476-5381.1981.tb16791.x.
2
Cardiac alpha-adrenoceptors involving positive chronotropic responses.
J Cardiovasc Pharmacol. 1985;7 Suppl 6:S121-6. doi: 10.1097/00005344-198500076-00020.
3
alpha 1-adrenoceptor activation can increase heart rate directly or decrease it indirectly through parasympathetic activation.α1肾上腺素能受体激活可直接增加心率，或通过激活副交感神经间接降低心率。
Br J Pharmacol. 1982 Oct;77(2):319-28. doi: 10.1111/j.1476-5381.1982.tb09301.x.
4
Involvement of alpha 1-adrenoceptors in chronotropic responses to endogenously released amines in the pithed rat.
Clin Exp Pharmacol Physiol. 1988 Jan;15(1):33-41. doi: 10.1111/j.1440-1681.1988.tb01006.x.
5
Characterization of the alpha-adrenoceptors mediating positive inotropy of rat left atria by use of selective agonists and antagonists.利用选择性激动剂和拮抗剂对介导大鼠左心房正性肌力作用的α-肾上腺素能受体进行表征。
Arch Int Pharmacodyn Ther. 1987 Feb;285(2):181-98.
6
Alpha-adrenoceptor-mediated chronotropic response: influence of temperature and basal spontaneous rate.α-肾上腺素能受体介导的变时反应：温度和基础自发率的影响
Naunyn Schmiedebergs Arch Pharmacol. 1989 Mar;339(3):315-9. doi: 10.1007/BF00173585.
7
alpha 1- and alpha 2-Adrenoceptor-mediated pressor and chronotropic effects in the rat and rabbit.α1和α2肾上腺素能受体介导的大鼠和家兔的升压和变时效应。
J Cardiovasc Pharmacol. 1982;4 Suppl 1:S101-7. doi: 10.1097/00005344-198200041-00021.
8
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Postjunctional alpha-adrenoceptors in the rabbit isolated distal saphenous artery: indirect sensitivity to prazosin of responses to noradrenaline mediated via postjunctional alpha 2-adrenoceptors.兔离体隐静脉远段的节后α-肾上腺素能受体：通过节后α2-肾上腺素能受体介导的对去甲肾上腺素反应对哌唑嗪的间接敏感性。
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10
Indications for vascular alpha- and beta-2 adrenoceptors in synapses of the muscarinic pathway in the pithed normotensive rat.去大脑正常血压大鼠毒蕈碱途径突触中血管α和β2肾上腺素能受体的指征
J Pharmacol Exp Ther. 1982 Oct;223(1):219-23.

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The Pharmacological Effects of Phenylephrine are Indirect, Mediated by Noradrenaline Release from the Cytoplasm.苯肾上腺素的药理学作用是间接的，通过从细胞质中释放去甲肾上腺素来介导。
Neurochem Res. 2022 Nov;47(11):3272-3284. doi: 10.1007/s11064-022-03681-2. Epub 2022 Aug 9.
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Alpha 1-adrenoceptors in the conduction system of rat hearts.
Br J Pharmacol. 1994 Feb;111(2):465-8. doi: 10.1111/j.1476-5381.1994.tb14759.x.
3
The use of neurally released agonist in the measurement of antagonism at alpha-adrenoceptors.在α-肾上腺素能受体拮抗作用测量中使用神经释放的激动剂。
Br J Pharmacol. 1983 Dec;80(4):655-61. doi: 10.1111/j.1476-5381.1983.tb10055.x.
4
Pharmacology of combined alpha-beta-blockade. I.α-β联合阻滞的药理学。I.
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alpha 1-adrenoceptor activation can increase heart rate directly or decrease it indirectly through parasympathetic activation.α1肾上腺素能受体激活可直接增加心率，或通过激活副交感神经间接降低心率。
Br J Pharmacol. 1982 Oct;77(2):319-28. doi: 10.1111/j.1476-5381.1982.tb09301.x.
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Eur J Appl Physiol Occup Physiol. 1986;54(6):617-23. doi: 10.1007/BF00943350.
8
Structure and alpha-adrenergic activity of pyrazinimidazolines.吡嗪咪唑啉类化合物的结构与α-肾上腺素能活性
Agents Actions. 1985 Jul;16(5):435-42. doi: 10.1007/BF01982885.
9
Effect of artificial respiratory volume on the cardiovascular responses to an alpha 1- and an alpha 2-adrenoceptor agonist in the air-ventilated pithed rat.人工呼吸量对通气去大脑大鼠心血管系统对α1和α2肾上腺素能受体激动剂反应的影响。
Br J Pharmacol. 1988 Apr;93(4):781-90. doi: 10.1111/j.1476-5381.1988.tb11463.x.
10
Cardiac alpha-1 adrenoceptors are not involved in heart rate control of the anaesthetized dog.心脏α-1肾上腺素能受体不参与麻醉犬的心率调节。
Pflugers Arch. 1987 Nov;410(4-5):495-500. doi: 10.1007/BF00586531.

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AMIDEPHRINE--II: CARDIOVASCULAR ACTIONS OF A NEW SYMPATHOMIMETIC AMINE.酰胺福林——II：一种新型拟交感胺的心血管作用
Int J Neuropharmacol. 1965 Jul;4:235-44. doi: 10.1016/0028-3908(65)90039-0.
2
The distribution of adrenoceptors and other drug receptors between the two ends of the rat vas deferens as revealed by selective agonists and antagonists.选择性激动剂和拮抗剂揭示大鼠输精管两端肾上腺素能受体及其他药物受体的分布情况。
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3
A comparison of pre- and post-junctional potencies of several alpha-adrenoceptor agonists in the cardiovascular system and anococcygeus muscle of the rat. Evidence for two types of post-junctional alpha-adrenoceptor.几种α-肾上腺素能激动剂在大鼠心血管系统和尾骨肌中节前和节后效能的比较。两种节后α-肾上腺素能受体的证据。
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4
Effect of adrenergic agonists on tension development and rate in atria from euthyroid and hypothyroid rats.肾上腺素能激动剂对正常甲状腺和甲状腺功能减退大鼠心房张力发展及速率的影响。
Adv Myocardiol. 1980;1:417-35.
5
Interactions of sympathomimetic drugs, propranolol and phentolamine, on atrial refractory period and contractility.拟交感神经药物、普萘洛尔和酚妥拉明对心房不应期和收缩性的相互作用。
Br J Pharmacol Chemother. 1967 Aug;30(3):603-11. doi: 10.1111/j.1476-5381.1967.tb02166.x.
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Effect of hypothyroid status on myocardial responses to sympathomimetic drugs.甲状腺功能减退状态对心肌对拟交感神经药物反应的影响。
Jpn J Pharmacol. 1971 Dec;21(6):819-25. doi: 10.1254/jjp.21.819.
7
A method of stimulating different segments of the autonomic outflow from the spinal column to various organs in the pithed cat and rat.一种在脊髓被破坏的猫和大鼠中刺激从脊柱到各个器官的自主神经传出不同节段的方法。
Br J Pharmacol. 1970 Oct;40(2):257-67. doi: 10.1111/j.1476-5381.1970.tb09919.x.
8
Effects of isoprenaline and phenylephrine on energy-rich phosphate compounds and glucose-6-phosphate in smooth and cardiac muscle.异丙肾上腺素和去氧肾上腺素对平滑肌和心肌中高能磷酸化合物及6-磷酸葡萄糖的影响。
Br J Pharmacol. 1971 Nov;43(3):593-603. doi: 10.1111/j.1476-5381.1971.tb07189.x.
9
Evidence for the existence of alpha adrenergic receptor in isolated rat atria.在离体大鼠心房中存在α肾上腺素能受体的证据。
Jpn J Pharmacol. 1972 Apr;22(2):227-33. doi: 10.1254/jjp.22.227.
10
Effects of isomers of the alpha-agonist amidephrine on arterial and tracheal muscle in vitro.α-激动剂酰胺福林异构体对体外动脉和气管平滑肌的作用。
Eur J Pharmacol. 1970 May;10(2):293-6. doi: 10.1016/0014-2999(70)90286-4.

α1肾上腺素能受体可介导大鼠心脏的变时反应。

alpha 1-adrenoceptors can mediate chronotropic responses in the rat heart.

作者信息

Flavahan N A, McGrath J C

出版信息

Br J Pharmacol. 1981 Jul;73(3):586-8. doi: 10.1111/j.1476-5381.1981.tb16791.x.

DOI:10.1111/j.1476-5381.1981.tb16791.x
PMID:6265015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071683/
Abstract

In the pithed rat, amidephrine a "selective" alpha 1-adrenoceptor agonist, evokes a positive chronotropic response. This response can be antagonized by prazosin but not by propranolol or by rauwolscine. Similarly, part of the chronotropic response to cardioaccelerator nerve stimulation is resistant to blockade by propranolol but is sensitive to prazosin or WB4101. We conclude that alpha 1-adrenoceptors can mediate a chronotropic response in the rat heart either to exogenous agonists or to the endogenous neurotransmitter noradrenaline.

摘要

在脊髓横断的大鼠中，酰胺福林（一种“选择性”α1 -肾上腺素能受体激动剂）可引起正性变时反应。这种反应可被哌唑嗪拮抗，但不能被普萘洛尔或萝芙素拮抗。同样，对心脏加速神经刺激的部分变时反应对普萘洛尔的阻断有抗性，但对哌唑嗪或WB4101敏感。我们得出结论，α1 -肾上腺素能受体可介导大鼠心脏对外源性激动剂或内源性神经递质去甲肾上腺素的变时反应。