α1肾上腺素能受体可介导大鼠心脏的变时反应。
alpha 1-adrenoceptors can mediate chronotropic responses in the rat heart.
作者信息
Flavahan N A, McGrath J C
出版信息
Br J Pharmacol. 1981 Jul;73(3):586-8. doi: 10.1111/j.1476-5381.1981.tb16791.x.
Abstract
In the pithed rat, amidephrine a "selective" alpha 1-adrenoceptor agonist, evokes a positive chronotropic response. This response can be antagonized by prazosin but not by propranolol or by rauwolscine. Similarly, part of the chronotropic response to cardioaccelerator nerve stimulation is resistant to blockade by propranolol but is sensitive to prazosin or WB4101. We conclude that alpha 1-adrenoceptors can mediate a chronotropic response in the rat heart either to exogenous agonists or to the endogenous neurotransmitter noradrenaline.
摘要
在脊髓横断的大鼠中，酰胺福林（一种“选择性”α1 -肾上腺素能受体激动剂）可引起正性变时反应。这种反应可被哌唑嗪拮抗，但不能被普萘洛尔或萝芙素拮抗。同样，对心脏加速神经刺激的部分变时反应对普萘洛尔的阻断有抗性，但对哌唑嗪或WB4101敏感。我们得出结论，α1 -肾上腺素能受体可介导大鼠心脏对外源性激动剂或内源性神经递质去甲肾上腺素的变时反应。
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AMIDEPHRINE--II: CARDIOVASCULAR ACTIONS OF A NEW SYMPATHOMIMETIC AMINE.酰胺福林——II：一种新型拟交感胺的心血管作用
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A comparison of pre- and post-junctional potencies of several alpha-adrenoceptor agonists in the cardiovascular system and anococcygeus muscle of the rat. Evidence for two types of post-junctional alpha-adrenoceptor.几种α-肾上腺素能激动剂在大鼠心血管系统和尾骨肌中节前和节后效能的比较。两种节后α-肾上腺素能受体的证据。
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Interactions of sympathomimetic drugs, propranolol and phentolamine, on atrial refractory period and contractility.拟交感神经药物、普萘洛尔和酚妥拉明对心房不应期和收缩性的相互作用。
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Evidence for the existence of alpha adrenergic receptor in isolated rat atria.在离体大鼠心房中存在α肾上腺素能受体的证据。
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10
Effects of isomers of the alpha-agonist amidephrine on arterial and tracheal muscle in vitro.α-激动剂酰胺福林异构体对体外动脉和气管平滑肌的作用。
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