Zannad F, Royer R J, Issartel G, Robert J
Eur J Cardiol. 1981;12(5):285-96.
Na+,K+-ATPase activity was assessed indirectly in three groups of subjects of differing age, and in a group of patients with renal failure, by measuring the 86-rubidium uptake in the patients' own erythrocytes. The inhibiting action of digoxin on this activity was also measured in vitro. Erythrocyte 86Rb uptake was found to be lower in the elderly as was the calculated volume of distribution of digoxin. Sensitivity to the inhibiting action of digoxin increased with age. In the renal failure group 86Rb uptake was diminished and the sensitivity to digoxin was variable. This suggested that Na+,K+-ATPase activity could be one determinant of the volume of distribution of digoxin and that quantitative and qualitative changes of this enzyme could explain features of the pharmacokinetics of digoxin in renal failure and in old age.
通过测量患者自身红细胞对86铷的摄取，间接评估了三组不同年龄受试者以及一组肾衰竭患者的钠钾ATP酶活性。还在体外测量了地高辛对该活性的抑制作用。发现老年人红细胞对86铷的摄取较低，地高辛的计算分布容积也较低。对地高辛抑制作用的敏感性随年龄增加。在肾衰竭组中，86铷摄取减少，对地高辛的敏感性各不相同。这表明钠钾ATP酶活性可能是地高辛分布容积的一个决定因素，该酶的定量和定性变化可以解释地高辛在肾衰竭和老年患者中药代动力学的特征。
