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环磷酸鸟苷升高与动脉平滑肌舒张之间的解离关系。

Dissociation of increases in cyclic GMP from relaxation of arterial smooth muscle.

作者信息

Braughler J M

出版信息

Eur J Pharmacol. 1981 Feb 19;69(4):503-5. doi: 10.1016/0014-2999(81)90457-x.

DOI:10.1016/0014-2999(81)90457-x
PMID:6265232
Abstract

Glyceryl trinitrate increased the cyclic GMP content of epinephrine-contracted aortic strips from glyceryl trinitrate-tolerant rats in a dose-dependent manner. Glyceryl trinitrate (.05 millimicron/ml) at a concentration that caused to relaxation of aortas from tolerant animals but a 42.4 3.7% relaxation of control aortas, elevated cyclic GMP levels in both groups approximately 3-fold. The results are not consistent with the hypothesis that cyclic GMP is involved in the relaxation of arterial smooth muscle.

摘要

硝酸甘油以剂量依赖的方式增加了来自硝酸甘油耐受大鼠的肾上腺素收缩主动脉条的环鸟苷酸含量。硝酸甘油（0.05微摩尔/毫升）的浓度能使耐受动物的主动脉松弛，但只能使对照主动脉松弛42.4±3.7%，两组的环鸟苷酸水平均升高了约3倍。这些结果与环鸟苷酸参与动脉平滑肌松弛的假说不一致。

相似文献

1
Dissociation of increases in cyclic GMP from relaxation of arterial smooth muscle.环磷酸鸟苷升高与动脉平滑肌舒张之间的解离关系。
Eur J Pharmacol. 1981 Feb 19;69(4):503-5. doi: 10.1016/0014-2999(81)90457-x.
2
Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.环鸟苷酸 3':5'-单磷酸的生成与硝酸甘油、硝普钠、亚硝酸盐和一氧化氮对冠状动脉平滑肌舒张作用之间的关系：亚甲蓝和高铁血红蛋白的影响
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Biotransformation of glyceryl trinitrate and elevation of cyclic GMP precede glyceryl trinitrate-induced vasodilation.三硝酸甘油酯的生物转化及环磷酸鸟苷的升高先于三硝酸甘油酯诱导的血管舒张。
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Possible role for cyclic GMP in endothelium-dependent relaxation of rabbit aorta by acetylcholine. Comparison with nitroglycerin.环磷酸鸟苷在乙酰胆碱介导的兔主动脉内皮依赖性舒张中的可能作用。与硝酸甘油的比较。
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Nitroprusside increases cyclic guanylate monophosphate concentrations during relaxation of rabbit aortic strips and both effects are antagonized by cyanide.硝普钠在兔主动脉条舒张过程中可增加环磷酸鸟苷浓度，且这两种效应均被氰化物拮抗。
Anesthesiology. 1982 Oct;57(4):303-8. doi: 10.1097/00000542-198210000-00010.

引用本文的文献

1
Cyclic GMP may serve as a second messenger in peptide-induced muscle degeneration in an insect.环磷酸鸟苷（cGMP）可能作为昆虫中肽诱导的肌肉退化的第二信使。
Proc Natl Acad Sci U S A. 1984 Nov;81(21):6718-22. doi: 10.1073/pnas.81.21.6718.