Ali I U, Hunter T
J Biol Chem. 1981 Jul 25;256(14):7671-7.
Comparative study of the structures of fibronectins from normal and transformed cells by partial proteolysis as well as by tryptic peptide fingerprinting and analysis of phosphorylation show that: 1) fibronectin molecules from normal and transformed cells probably have very similar primary structures; 2) the phosphorylation of fibronectin is a highly specific and conserved phenomenon; 3) fibronectin from both normal and transformed cells is phosphorylated only on serine residues; 4) although the major sites of phosphorylation in fibronectin are the same in normal and transformed cells, fibronectin from transformed cells appears to be phosphorylated to a much higher extent than that from normal cells.
通过部分蛋白酶解、胰蛋白酶肽指纹图谱以及磷酸化分析对正常细胞和转化细胞的纤连蛋白结构进行的比较研究表明：1）正常细胞和转化细胞的纤连蛋白分子可能具有非常相似的一级结构；2）纤连蛋白的磷酸化是一种高度特异性和保守的现象；3）正常细胞和转化细胞的纤连蛋白仅在丝氨酸残基上发生磷酸化；4）尽管正常细胞和转化细胞中纤连蛋白的主要磷酸化位点相同，但转化细胞来源的纤连蛋白似乎比正常细胞来源的纤连蛋白磷酸化程度要高得多。
