Snyderman R, Goetzl E J
Science. 1981 Aug 21;213(4510):830-7. doi: 10.1126/science.6266014.
The application of modern scientific methods to the study of leukocyte function has begun to reveal the molecular and cytostructural bases of the chemotactic responses of these cells. Leukocyte chemotaxis is initiated by the binding of chemoattractants to distinct plasma membrane receptors; this finding alters transmembrane potential and activates ionic fluxes. The subsequent sequence of metabolic processes leads to a rearrangement of cytoskeletal elements that is manifested by orientation and migration of the cells toward the source of the chemotactic gradient.
将现代科学方法应用于白细胞功能研究已开始揭示这些细胞趋化反应的分子和细胞结构基础。白细胞趋化性由趋化因子与不同质膜受体结合引发；这一发现改变跨膜电位并激活离子通量。随后的代谢过程序列导致细胞骨架成分重排，表现为细胞朝着趋化梯度源定向和迁移。
