采用新的胰岛制备方法对慢性胰腺炎患者进行胰腺切除术后的胰岛自体移植。

Islet autotransplantation after pancreatectomy for chronic pancreatitis with a new method of islet preparation.

作者信息

Hinshaw D B, Jolley W B, Hinshaw D B, Kaiser J E, Hinshaw K

出版信息

Am J Surg. 1981 Jul;142(1):118-22. doi: 10.1016/s0002-9610(81)80020-7.

Abstract

Near-total (95 percent) pancreatectomy with intraportal islet autotransplantation was performed in five patients with chronic pancreatitis. Two patients are completely insulin-independent 7 and 14 months after autotransplantation; the other three patients obtained partial independence. A new method of islet cell preparation is described. Islet cell autotransplantation after total or near-total pancreatectomy should at present be viewed with cautious optimism. Additional cases need to be studied and followed up before its role in the surgery of chronic pancreatitis will be clear.

摘要

对5例慢性胰腺炎患者实施了门静脉内胰岛自体移植的近全胰腺切除术（切除95%）。2例患者在自体移植后7个月和14个月完全停用胰岛素；另外3例患者部分停用胰岛素。描述了一种新的胰岛细胞制备方法。目前，对于全胰腺或近全胰腺切除术后的胰岛细胞自体移植应持谨慎乐观的态度。在其在慢性胰腺炎手术中的作用明确之前，还需要研究和随访更多病例。