Kemppainen R J, Lorenz M D, Thompson F N
Am J Vet Res. 1981 May;42(5):822-4.
Adrenal function was assessed in dogs after intramuscular administration of a single dose of methylprednisolone acetate (MPA). Twelve dogs were test challenged with adrenocorticotropic hormone (ACTH) and then assigned randomly to 1 of 3 groups and given MPA. Individual groups were test challenged with ACTH 2, 3, or 4 weeks later. All dogs were rechallenged 5 weeks after MPA administration. Plasma cortisol concentration was determined by radioimmunoassay. Basal plasma cortisol (time 0) was depressed on weeks 2 and 3, but not on weeks 4 and 5. Adrenal response to ACTH (increment of cortisol change) was suppressed on weeks 2, 4, and 5, but not on week 3. It was concluded that a single dose of MPA is capable of altering adrenal cortical function in dogs for at least 5 weeks.
在犬类肌肉注射单剂量醋酸甲泼尼龙（MPA）后评估其肾上腺功能。12只犬接受促肾上腺皮质激素（ACTH）激发试验，然后随机分为3组之一并给予MPA。分别在2、3或4周后对各个组进行ACTH激发试验。所有犬在给予MPA 5周后再次接受激发试验。通过放射免疫分析法测定血浆皮质醇浓度。基础血浆皮质醇（0时刻）在第2周和第3周降低，但在第4周和第5周未降低。肾上腺对ACTH的反应（皮质醇变化增量）在第2、4和5周受到抑制，但在第3周未受抑制。得出的结论是，单剂量MPA能够在至少5周内改变犬类的肾上腺皮质功能。
