[Analysis of the excitable properties of an artificial membrane containing amphotericin B in the presence of cationic blockers].

A mathematical model was developed to describe the excitability of the amphotericin B--containing membrane with ionic blockers. The model is equivalent to the Hodgkin--Huxley model of the Na--channel with only one activating particle. A variety of the blockers parameters were evaluated with which the artificial membrane acquires excitable properties (generation of action potential, a self--oscillatory mode of pulse generation, trigger--like changes in the resting potential). The possibilities of constructing artificial excitable membranes with a cooperative activation of conductivity are discussed.