Bulatov A A, Dzhaliashvili T A, Pankov Iu A
Biull Eksp Biol Med. 1981 Apr;91(4):429-31.
Effects of seiwhale somatotropin (STH), its biologically active fragment 77--107, porcine corticotropin (ACTH) and seiwhale prolactin on phosphodiesterase and adenylate cyclase activity of glial cells and synaptosomes isolated from the rat brain cortex were investigated. As compared with control, ACTH increased phosphodiesterase activity of glial cells by 392%, of synaptosomes by 123%, while STH by 49 and 77%, respectively, somatotropin fragment by 455 and 74%, and prolactin by 30 and 37%, respectively. Adenylate cyclase activity was significantly changed only by ACTH and only in synaptosomes (a 50% decrease). STH, its fragment and prolactin virtually failed to alter adenylate cyclase activity. The data obtained indicate that some of pituitary hormones, primarily ACTH and STH, may play the role of neuromodulators in some brain structures by decreasing the cyclic AMP level, by activating phosphodiesterase (STH and ACTH) and inhibiting adenylate cyclase (ACTH in synaptosomes).
研究了大须鲸生长激素（STH）、其生物活性片段77 - 107、猪促肾上腺皮质激素（ACTH）和大须鲸催乳素对从大鼠大脑皮层分离的神经胶质细胞和突触体的磷酸二酯酶和腺苷酸环化酶活性的影响。与对照组相比，ACTH使神经胶质细胞的磷酸二酯酶活性增加392%，使突触体的磷酸二酯酶活性增加123%，而STH分别使神经胶质细胞和突触体的磷酸二酯酶活性增加49%和77%，生长激素片段分别使其增加455%和74%，催乳素分别使其增加30%和37%。腺苷酸环化酶活性仅在ACTH作用下且仅在突触体中发生显著变化（降低50%）。STH及其片段和催乳素实际上未能改变腺苷酸环化酶活性。所获得的数据表明，一些垂体激素，主要是ACTH和STH，可能通过降低环磷酸腺苷水平、激活磷酸二酯酶（STH和ACTH）以及抑制腺苷酸环化酶（突触体中的ACTH）在某些脑结构中发挥神经调质的作用。
