Schaefer K, von Herrath D
Klin Wochenschr. 1981 Jun 1;59(11):525-34. doi: 10.1007/BF01716452.
Vitamin D3 and its various metabolites have a central position in the regulation of the calcium- and phosphorus metabolism. Of special importance is 1,25-dihydroxyvitamin D3, which is almost exclusively synthesized in the kidney. Its production is dependent upon several hormonal stimuli and of course occurs normally only in intact renal tissue. The multifactorial regulation of its formation implies that a variety of diseases could cause disturbances in the metabolism of vitamin D. 1,25-dihydroxyvitamin D3 exerts its biological effects not only at the intestine, bone and kidney, but as well presumably in organs as the parathyroid glands, hypophysis, pancreas and skin. 24,25-dihydroxyvitamin D3--although its biological value is still in debate--represents possibly a second vitamin D-hormone of importance. Inspite of intensive research work the metabolic fate of vitamin D3 and its full biological significance is not yet entirely understood.
维生素D3及其多种代谢产物在钙磷代谢调节中占据核心地位。尤为重要的是1,25 - 二羟维生素D3，它几乎完全在肾脏中合成。其生成依赖于多种激素刺激，当然通常仅在完整的肾组织中发生。其形成的多因素调节意味着多种疾病可能导致维生素D代谢紊乱。1,25 - 二羟维生素D3不仅在肠道、骨骼和肾脏发挥生物学作用，而且可能在甲状旁腺、垂体、胰腺和皮肤等器官中也有作用。24,25 - 二羟维生素D3——尽管其生物学价值仍存在争议——可能代表另一种重要的维生素D激素。尽管进行了深入的研究工作，但维生素D3的代谢命运及其全部生物学意义尚未完全明确。
