促肾上腺皮质激素1-24与β-内啡肽在大鼠体内的相互拮抗作用。
Reciprocal antagonism between ACTH1-24 and beta-endorphin in rats.
作者信息
Fratta W, Rossetti Z L, Poggioli R, Gessa G L
出版信息
Neurosci Lett. 1981 Jun 12;24(1):71-4. doi: 10.1016/0304-3940(81)90361-x.
PMID:6267526
Abstract
ACTH1-24 and beta-endorphin simultaneously injected at 5-10 microgram dose into the lateral ventricle, reciprocally suppress most of their respective behavioural effects (stretching-yawning syndrome, sexual excitement and hyperalgesia for ACTH1-24 and catalepsy and analgesia for beta-endorphin). The results obtained support the hypothesis that ACTH1-24 and beta-endorphin might interact antagonistically at CNS level.
摘要
将促肾上腺皮质激素1-24（ACTH1-24）和β-内啡肽以5-10微克的剂量同时注入侧脑室时，它们会相互抑制彼此的大部分行为效应（ACTH1-24引起的伸展-打哈欠综合征、性兴奋和痛觉过敏，以及β-内啡肽引起的僵住症和镇痛）。所得结果支持这样一种假说，即ACTH1-24和β-内啡肽可能在中枢神经系统水平上产生拮抗作用。
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