Soboleva E L, Goncharova A Ia, Norets T A, Stepanenko V F, Komarov V P
Biull Eksp Biol Med. 1978 Jan;85(1):20-3.
A method of radiometry in vivo was applied to study the regularities attending distribution of the absorbed dose and its formation in the course of one year after the administration of 0.033 muCu/g of selenomethionine-75Se to rats, as well as the functional condition of the adaptive hypophysis-adrenal glands system by the determination of plasma corticosterone. A high tropicity of this preparation to the endocrine system organs was demonstrated. Intensification of the functional activity of the adaptive system was indicated by an increase of the blood plasma corticosterone concentration following the administration of a, radioactive preparation and its statistically significant increase (in comparison with control) 3, 6, and 10 months from the beginning of the experiment. The action of acute stress (histamine and formalin) 10 months after the administration of selenomethionine-75Se caused no sharp elevation of the plasma corticosterone concentration characteristic of control rats, this indicating an extreme strain of the hypophysis-adrenal gland system and its incapacity to respond to additional loads. It is supposed that analysis of functional condition of the adaptive system could serve as the key in the assessment of the biological effect of low radiation doses.
采用体内辐射测量法，研究给大鼠注射0.033μCi/g的硒代蛋氨酸-75Se后一年内吸收剂量的分布规律及其形成过程，以及通过测定血浆皮质酮来研究适应性垂体-肾上腺系统的功能状态。结果表明该制剂对内分泌系统器官具有高度嗜性。给予放射性制剂后血浆皮质酮浓度升高，且在实验开始后的3、6和10个月与对照组相比有统计学意义的显著升高，表明适应性系统的功能活性增强。在注射硒代蛋氨酸-75Se 10个月后施加急性应激（组胺和福尔马林），并未引起对照大鼠血浆皮质酮浓度的急剧升高，这表明垂体-肾上腺系统极度紧张且无法对额外负荷做出反应。据推测，适应性系统功能状态的分析可能是评估低辐射剂量生物效应的关键。
