酮康唑所致男性乳房发育症
Gynecomastia with ketoconazole.
作者信息
DeFelice R, Johnson D G, Galgiani J N
出版信息
Antimicrob Agents Chemother. 1981 Jun;19(6):1073-4. doi: 10.1128/AAC.19.6.1073.
Abstract
Three of forty men developed bilateral gynecomastia upon ketoconazole treatment. Symptoms abated despite continued therapy. This appears to be a direct drug effect on breast tissue.
摘要
40名男性中有3名在接受酮康唑治疗后出现双侧乳腺增生。尽管继续治疗，症状仍有所减轻。这似乎是药物对乳腺组织的直接作用。
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本文引用的文献
1
Gynecomastia. Its incidence, recognition and host characterization in 447 autopsy cases.
Am J Med. 1963 Jan;34:103-12. doi: 10.1016/0002-9343(63)90044-5.
2
Gynecomastia during digitalis therapy; report of eight additional cases with liver-function studies.洋地黄治疗期间的男性乳腺增生；另外八例肝功能研究报告
N Engl J Med. 1953 Feb 19;248(8):316-20. doi: 10.1056/NEJM195302192480802.
3
Ketoconazole: a major innovation for treatment of fungal disease.酮康唑：治疗真菌病的一项重大创新。
Ann Intern Med. 1980 Dec;93(6):921-3. doi: 10.7326/0003-4819-93-6-921.
4
Therapy of disseminated or pulmonary coccidioidomycosis with ketoconazole.
Rev Infect Dis. 1980 Jul-Aug;2(4):656-60. doi: 10.1093/clinids/2.4.656.
5
Estrogen-like activity of digitalis: its effect on the squamous epithelium of the female genital tract.洋地黄的雌激素样活性：其对女性生殖道鳞状上皮的影响。
JAMA. 1965 Oct 4;194(1):30-2. doi: 10.1001/jama.194.1.30.
6
Case report. Gynecomastia following digitalis administration.病例报告。服用洋地黄后出现男性乳房发育。
J Fla Med Assoc. 1975 Dec;62(12):54-5.
7
Estrogen metabolism in hyperthyroidism and in cirrhosis of the liver.甲状腺功能亢进症和肝硬化中的雌激素代谢
Steroids. 1975 Jul;26(1):47-56. doi: 10.1016/0039-128x(75)90005-7.
8
Conversion of androgens to estrogens in cirrhosis of the liver.肝脏肝硬化中雄激素向雌激素的转化。
J Clin Endocrinol Metab. 1975 Jun;40(6):1018-26. doi: 10.1210/jcem-40-6-1018.
9
Spironolactone and endocrine dysfunction.
Ann Intern Med. 1976 Nov;85(5):630-6. doi: 10.7326/0003-4819-85-5-630.
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