Webb J A, Fry I K, Cattell W R, Cummack B, Jewell S E
Br J Radiol. 1978 Feb;51(602):106-10. doi: 10.1259/0007-1285-51-602-106.
The urinary iodine concentrations of a monomer (sodium iothalamate), a dimer (sodium iocarmate) and a non-ionic compound (metrizamide) have been compared in dogs with varying levels of solute excretion. All the animals were undergoing maximal antidiuresis. In dogs with normal solute excretion, metrizamide and iocarmate produced higher urinary iodine concentrations than iothalamate. There was no significant difference between metrizamide and iocarmate. With increasing levels of solute excretion, the differences between the compounds were reduced. These findings suggest that contrast media of reduced osmolality are unlikely to have a special place in advanced renal failure.
在溶质排泄水平不同的犬类中，比较了一种单体（碘他拉酸钠）、一种二聚体（碘卡明酸钠）和一种非离子化合物（甲泛葡胺）的尿碘浓度。所有动物均处于最大抗利尿状态。在溶质排泄正常的犬类中，甲泛葡胺和碘卡明酸钠产生的尿碘浓度高于碘他拉酸钠。甲泛葡胺和碘卡明酸钠之间无显著差异。随着溶质排泄水平的增加，这些化合物之间的差异减小。这些发现表明，低渗造影剂在晚期肾衰竭中不太可能占据特殊地位。
