Solute excretion during intravenous urography. A comparison of sodium iothalamate and sodium iocarmate (iothalamate dimer).

Sodium iothalamate and sodium iocarmate (iothalamate dimer) were compared as urographic agents. The two agents were administered intravenously to dogs at a dose level of 600 mg I/kg. The concentrations and outputs of major urinary solutes and injected solutes were measured to define the differences in diuretic effect of the two agents. The urinary output and concentration of iodine with each agent were also compared. The diuresis with iocarmate was lower. It was apparent that the lower diuresis and higher urinary iodine concentration with iocarmate was due to the lower osmotic activity per iodine atom obtained with this agent.