Phosphoglucomutase, adenylate kinase and acid phosphatase polymorphism in some Jewish populations of Israel.

The phosphoglucomutase (PGM1) adenylate kinase (AK1) and acid phosphatase (ACP1) phenotypes were studied in Israeli Jews. In total 934 individuals were investigated for AK1 and of these, 926 for PGM1 and 768 for ACP1 isozymes. From the studied individuals, six groups deriving from Eastern, Central and Southern Europe, the Middle East, North Africa and Yemen were formed. The comparison of the phenotype distribution in these groups by the chi-square test failed to indicate any statistically significant differences with respect to PGM1 phenotypes. With respect to AK1 phenotypes, there were statistically significant differences between the Central European group on the one hand and the Yemenite and South European groups on the other (p less than 0.05), and with respect to ACP1--between the Middle Eastern and the Yemenite groups (p less than 0.01). In the studied groups, the frequency of the PGM11 gene varied from 0.6822 (North African group) to 0.7431 (Central European group), of the AK11 gene--from 0.9099 (Central European group) to 0.9698 (Yemenite group) and of the ACPb1 gene--from 0.6710 (Middle Eastern group) to 0.8194 (Yemenite group). The greatest genetic distances were found between the Yemenite group on the one hand and the Middle Eastern, Central European and East European subgroups on the other.