传染性单核细胞增多症中的B淋巴细胞减少症。
B lymphocytopenia in infectious mononucleosis.
作者信息
Sumaya C V, Keightley R G
出版信息
Clin Exp Immunol. 1981 Feb;43(2):298-301.
Changes in lymphocyte surface markers during Epstein-Barr virus (EBV) associated infectious mononucleosis (IM) were re-examined because (1) these changes may provide information about host immune restraints to the initiation of a malignant process and (2) problems in the identification of B lymphocytes were often not appreciated in previous observations. An acute and transient reduction of IgM- and IgD-bearing B lymphocytes in the peripheral blood of these patients was demonstrated. The numbers of cells bearing Fc receptors and T lymphocytes were less consistently altered. It is hypothesized that the reduction of IgM- and IgD-bearing cells is caused by interference with the production of these cells or alternately their elimination by the virus or activated T lymphocytes.
对爱泼斯坦-巴尔病毒（EBV）相关传染性单核细胞增多症（IM）期间淋巴细胞表面标志物的变化进行了重新研究，原因如下：（1）这些变化可能提供有关宿主对恶性过程启动的免疫抑制信息；（2）以往观察中常常未充分认识到B淋巴细胞识别方面的问题。结果表明，这些患者外周血中携带IgM和IgD的B淋巴细胞出现急性和短暂减少。携带Fc受体的细胞和T淋巴细胞数量的变化则不太一致。据推测，携带IgM和IgD细胞的减少是由于这些细胞的产生受到干扰，或者是被病毒或活化的T淋巴细胞清除所致。
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