Klein E, Ernberg I, Masucci M G, Szigeti R, Wu Y T, Masucci G, Svedmyr E
Cancer Res. 1981 Nov;41(11 Pt 1):4210-5.
After Epstein-Barr virus (EBV) infection in vivo, B-cells with latent virus infection persist indefinitely through life. These cells grow in vitro on explanation and can be established as immortal B-cell lines. To reconcile the unlimited growth potential in vitro with the maintenance of a low proportion of B-cells infected by EBV in vivo, a strict in vivo control mechanism has to be postulated. Certain aspects of this control are apparent when the primary infection is followed by infectious mononucleosis. This is characterized by lymphocytosis and the presence of activated T-cells. The T-cell proliferation is probably the manifestation of the immune response against EBV antigens. However, the reaction of T-cells upon encounter of B-blasts is also likely to contribute to the events. At present, it is difficult to detect an EBV-specific component in the action of the T-cells in the acute phase of mononucleosis exerted on B-cells. However, for the clinical course of the disease the activation of T-cells is important. The activated T-cells may control and also eliminate the B-cells infected by EBV. In addition to the immunity which develops during the disease, th immunoregulatory mechanism is likely to have a role in the inhibition of B-cell proliferation.
在爱泼斯坦-巴尔病毒（EBV）在体内感染后，携带潜伏病毒感染的B细胞会终生无限期持续存在。这些细胞在体外培养时会生长，并可建立为永生B细胞系。为了使体外的无限生长潜力与体内被EBV感染的B细胞维持低比例相协调，必须假定存在一种严格的体内控制机制。当原发性感染后发生传染性单核细胞增多症时，这种控制的某些方面就很明显了。其特征是淋巴细胞增多以及存在活化的T细胞。T细胞增殖可能是针对EBV抗原的免疫反应的表现。然而，T细胞在遇到B母细胞时的反应也可能促成这些事件。目前，在传染性单核细胞增多症急性期T细胞对B细胞的作用中，很难检测到EBV特异性成分。然而，对于疾病的临床病程而言，T细胞的活化很重要。活化的T细胞可能控制并消除被EBV感染的B细胞。除了疾病期间产生的免疫外，免疫调节机制可能在抑制B细胞增殖中起作用。
