Kawamura H, Gunn C G, Frohlich E D
Brain Res. 1978 Jan 20;140(1):137-47. doi: 10.1016/0006-8993(78)90243-3.
Biphasic electrical stimulation of the nucleus locus coeruleus (LC) produced frequency-related pressor responses associated with increased heart rate in normotensive rats (WKY) at both 50 and 100 microamperemeter. In contrast, spontaneously hypertensive rats (SHR) demonstrated small depressor responses at 50 microamperemeter and 50 Hz, but no consistent pressure or heart rate changes at either 50 or 100 muA stimulation. The LC pressor threshold current (current necessary to increase arterial pressure by greater than or equal 10 mm Hg) was higher in SHR than WKY (136 +/- 5 muA vs. 84 +/- 7 muA; P less than 0.001); and only the SHR LC demonstrated a depressor threshold (current necessary to reduce arterial pressure by greater than or equal to 10 mm Hg) (53 +/- 3 muA). These threshold current levels did not seem to change with acute alterations of arterial pressure produced by either bilateral carotid artery occlusion or caortid sinus stimulation. Therefore, these studies indicate altered levels of responsiveness of the SHR LC to stimulation but that the pressor function of the LC does not seem to be importantly involved in further elevation of abnormally high arterial pressure in the SHR.
在正常血压大鼠（WKY）中，对蓝斑核（LC）进行双相电刺激，在50和100微安时均产生与心率增加相关的频率依赖性升压反应。相比之下，自发性高血压大鼠（SHR）在50微安和50赫兹时表现出小的降压反应，但在50或100微安刺激下，血压或心率均无一致变化。SHR的LC升压阈值电流（使动脉压升高大于或等于10毫米汞柱所需的电流）高于WKY（136±5微安对84±7微安；P＜0.001）；并且只有SHR的LC表现出降压阈值（使动脉压降低大于或等于10毫米汞柱所需的电流）（53±3微安）。这些阈值电流水平似乎不会因双侧颈动脉闭塞或颈动脉窦刺激引起的动脉压急性改变而改变。因此，这些研究表明SHR的LC对刺激的反应性水平发生了改变，但LC的升压功能似乎并未在SHR异常高血压的进一步升高过程中起重要作用。
