Conradt A, Schlotter C M, Weber H, Heller S
Geburtshilfe Frauenheilkd. 1976 Oct;36(10):862-8.
From 1973 to 1975, 287 serum levels of alpha 1 fetoprotein in women with pre-eclamptic toxemia were determined. Pre-eclamptic toxemia was classified according to modified scheme of Goecke and Rippmann. 161 patients had mild pre-eclamptic toxemia (index 1-3), 72 patients had moderate pre-eclamptic toxemia (index 4-6), 54 patients had severe pre-eclamptic toxemia (index 7). In all types of severity of pre-eclamptic toxemia more levels of alpha fetoprotein were lower or higher than the normal levels including the standard deviations. The number of abnormal values rose with an increasing toxemia index. There was no statistically significant difference between too high values and too low values. Significantly more values were above and also below the normal values. Our investigations appear to indicate that the determination of the alpha fetoprotein is not only valuable as screening method for neural tube defects but also of value in the diagnosis and management of pre-eclamptic toxemia. Too high and too low values should not be differentiated but values both above and below the normal levels should be considered.
1973年至1975年期间，测定了287例先兆子痫妇女的血清甲胎蛋白水平。先兆子痫根据Goecke和Rippmann的改良方案进行分类。161例患者患有轻度先兆子痫（指数1 - 3），72例患者患有中度先兆子痫（指数4 - 6），54例患者患有重度先兆子痫（指数7）。在先兆子痫的所有严重程度类型中，包括标准差在内，更多的甲胎蛋白水平低于或高于正常水平。异常值的数量随着子痫前期指数的增加而上升。过高值和过低值之间没有统计学上的显著差异。高于和低于正常值的数值均显著更多。我们的研究似乎表明，甲胎蛋白的测定不仅作为神经管缺陷的筛查方法有价值，而且在先兆子痫的诊断和管理中也有价值。不应区分过高和过低值，而应考虑高于和低于正常水平的数值。
