Durkot M J, Wolfe R R
Am J Physiol. 1981 Sep;241(3):R222-7. doi: 10.1152/ajpregu.1981.241.3.R222.
We have used the primed-constant infusion of [6-3H]glucose to study the effects of phentolamine, an alpha-adrenergic blocker, and propranolol, a beta-adrenergic blocker, on glucose production and clearance in gastrostomy-fed control, septic (repeated sub-Q Escherichia coli injections), and burned (25-30% BSA) guinea pigs. Hypermetabolism and elevated glucoregulatory hormones were evident in both traumatized models, whereas their glucose kinetic response was different. Basal glucose production and clearance were elevated in the burned group and were depressed in the septic group when compared to control values. Propranolol caused a further increase in glucose production and clearance in the burned group, whereas it depressed glucose production and clearance to an even greater extent in the septic group. Phentolamine also produced an increase in glucose production and clearance in the burned group. In the septic group, phentolamine had no significant effect on glucose production, but clearance was significantly elevated. Thus, although alpha- or beta-adrenergic blockade normalized metabolic rate in both groups with respect to control animals, glucose kinetics remained different despite similar changes in counterregulatory hormones.
我们采用[6-³H]葡萄糖的标记常量输注法，研究了α-肾上腺素能阻滞剂酚妥拉明和β-肾上腺素能阻滞剂普萘洛尔对经胃造口喂养的对照豚鼠、脓毒症豚鼠（反复皮下注射大肠杆菌）和烧伤豚鼠（25-30%体表面积烧伤）葡萄糖生成和清除的影响。两种创伤模型均出现高代谢和糖调节激素升高，但其葡萄糖动力学反应不同。与对照值相比，烧伤组基础葡萄糖生成和清除增加，脓毒症组则降低。普萘洛尔使烧伤组葡萄糖生成和清除进一步增加，而在脓毒症组中，它使葡萄糖生成和清除降低的程度更大。酚妥拉明也使烧伤组葡萄糖生成和清除增加。在脓毒症组中，酚妥拉明对葡萄糖生成无显著影响，但清除显著升高。因此，尽管α-或β-肾上腺素能阻断使两组的代谢率相对于对照动物恢复正常，但尽管反调节激素有类似变化，葡萄糖动力学仍存在差异。
