Las M S, Surks M I
Endocrinology. 1981 Oct;109(4):1259-63. doi: 10.1210/endo-109-4-1259.
To determine the relationship between the concentrations of serum T3 and hepatic nuclear T3 receptor in a reversible nonthyroidal disease, we studied these parameters in rats with streptozotocin-induced diabetes mellitus, control rats, and rats that were weight-matched to the diabetic rats by food restriction. Results were similar either 1 or 9 weeks after the induction of diabetes. A significant decrease from control in mean serum T4, T3 and free T3 index was noted in the diabetic rats. However, mean serum TSH was not altered significantly. The hepatic nuclear T3-binding capacity in the diabetic rats was similar to that in the control at both time intervals, whereas the nuclear T3-binding capacity of fasted rats was decreased. The dissociation of serum T3 and hepatic nuclear receptor concentrations in diabetic rats suggests that receptor concentration is not modified by thyroid hormones in this nonthyroidal disease.
为了确定在一种可逆性非甲状腺疾病中血清T3浓度与肝细胞核T3受体之间的关系，我们在链脲佐菌素诱导的糖尿病大鼠、对照大鼠以及通过限制饮食使其体重与糖尿病大鼠相匹配的大鼠中研究了这些参数。糖尿病诱导后1周或9周的结果相似。糖尿病大鼠的血清T4、T3和游离T3指数均值与对照相比显著降低。然而，血清TSH均值没有明显改变。糖尿病大鼠在两个时间点的肝细胞核T3结合能力与对照相似，而禁食大鼠的细胞核T3结合能力降低。糖尿病大鼠血清T3与肝细胞核受体浓度的解离表明，在这种非甲状腺疾病中，受体浓度不受甲状腺激素的影响。
