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巨细胞病毒免疫复合物与宿主细胞的相互作用。

Interaction of cytomegalovirus immune complexes with host cells.

作者信息

Rundell B B, Betts R F

出版信息

Infect Immun. 1981 Sep;33(3):658-65. doi: 10.1128/iai.33.3.658-665.1981.

DOI:10.1128/iai.33.3.658-665.1981
PMID:6269997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC350758/
Abstract

After adsorption to host cells of a mixture of cytomegalovirus (CMV) and immunoglobulin G (IgG)-anti CMV, at least 99% of the surviving fraction consisted of infectious virus-antibody complexes which could be neutralized by anti-human IgG antibody. The virus-antibody complexes penetrated into cells and were uncoated more slowly than native virus. When the virus-antibody complexes were treated with anti-human IgG antibody before adsorption was allowed to take place, anti-human IgG antibody immune complexes were adsorbed to host cells less readily and uncoated less efficiently than were untreated complexes. Furthermore, after adsorption, anti-human IgG antibody-IgG-CMV complexes were further retarded in their penetration and uncoating. These observations suggest that neutralization of CMV by IgG-anti-CMV resulted from interference with the normal mechanisms of penetration and uncoating. Anti-human IgG antibody enhanced the degree of neutralization by augmenting the inhibitory effect of antibody on these stages of virus-host interaction and also reduced adsorption of the complex.

摘要

巨细胞病毒（CMV）与免疫球蛋白G（IgG）-抗CMV的混合物吸附到宿主细胞后，至少99%的存活部分由可被抗人IgG抗体中和的感染性病毒-抗体复合物组成。病毒-抗体复合物进入细胞，其脱壳速度比天然病毒慢。当在允许吸附发生之前用抗人IgG抗体处理病毒-抗体复合物时，抗人IgG抗体免疫复合物比未处理的复合物更不易吸附到宿主细胞上，脱壳效率也更低。此外，吸附后，抗人IgG抗体-IgG-CMV复合物在穿透和脱壳方面进一步延迟。这些观察结果表明，IgG-抗CMV对CMV的中和作用是由于干扰了正常的穿透和脱壳机制。抗人IgG抗体通过增强抗体对病毒-宿主相互作用这些阶段的抑制作用，提高了中和程度，并且还减少了复合物的吸附。

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4
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5
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6
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8
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