Bonta I L, Adolfs M J, Parnham M J
Prostaglandins. 1981 Jul;22(1):95-103. doi: 10.1016/0090-6980(81)90056-3.
In the carrageenin-induced granuloma of rats the inflammatory tissue growth and macrophage invasion on the one hand and the cyclic-AMP content of the macrophages on the other, display opposite directional changes. Macrophages, isolated from this tissue at different stages of inflammation, were used to examine the effect of prostaglandin E2 on intracellular levels of c-AMP. It appears that during infiltration of the macrophages into the inflammatory tissue, the sensitivity of adenylate cyclase to activation by PGE2 increases. Arguments are presented that these observations made in vitro, are in direct relevance to the previous described anti-inflammatory effect of PGE on granuloma tissue in vivo.
在角叉菜胶诱导的大鼠肉芽肿中，一方面炎症组织生长和巨噬细胞浸润，另一方面巨噬细胞的环磷酸腺苷（c-AMP）含量呈现相反的方向性变化。从炎症不同阶段的该组织中分离出巨噬细胞，用于检测前列腺素E2对细胞内c-AMP水平的影响。似乎在巨噬细胞浸润到炎症组织的过程中，腺苷酸环化酶对前列腺素E2激活的敏感性增加。有证据表明，这些体外观察结果与先前描述的前列腺素E对体内肉芽肿组织的抗炎作用直接相关。
