Vasiliades J, Pollock J, Robinson C A
Clin Chem. 1978 Feb;24(2):383-5.
We describe a case of ethanol and isopropanol ingestion that resulted in coma. The concentration of ethanol and isopropanol was 0.90 and 1.65 g/liter in serum and 3.12 and 5.34 g/liter in gastric contents. With an enzymatic (alcohol dehydrogenase) method for ethanol determination we obtained erroneous analytical results. Because of partial cross reactivity with isopropanol, ethanol concentration was overestimated and total alcohol (i.e., the contribution of isopropanol) was underestimated. This was recognized by measuring serum osmolality. Differences between measured and calculated serum osmolality that are not accounted for by the serum ethanol concentration as determined by an enzymatic ethanol method must be further investigated by specific methods to see if other alcohols are present.
我们描述了一例因摄入乙醇和异丙醇导致昏迷的病例。血清中乙醇和异丙醇的浓度分别为0.90克/升和1.65克/升，胃内容物中分别为3.12克/升和5.34克/升。使用酶法（酒精脱氢酶）测定乙醇时，我们得到了错误的分析结果。由于与异丙醇存在部分交叉反应性，乙醇浓度被高估，而总酒精量（即异丙醇的贡献）被低估。通过测量血清渗透压才认识到这一点。对于酶法测定的血清乙醇浓度无法解释的实测血清渗透压与计算血清渗透压之间的差异，必须通过特定方法进一步研究，以确定是否存在其他醇类。
